hrp0097p2-22 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2023

Hyperinsulinaemic Hypoglycaemia in Term Neonates Without Known Risk Factors Leading to Neurological Damage: A Case Series of 5 Patients From Two Regional Centres in the UK

O'Reilly Freya , Monaghan Marie , Moran Matthew , Gubaeva Diliara , Senniappan Senthil , Likeman Marcus , Giri Dinesh , Amin Sam

Background: Little is known about the prevalence of neonatal hypoglycaemia in the absence of known risk factors, nor its associated neurodevelopmental outcomes. Neurological harm from hyperinsulinism induced hypoglycaemia (HH) may be due to the direct effect of hypoglycaemia as well as its sequelae, such as seizures or apnoeas, leading to secondary insults such as hypoxic brain injury. With our case series we highlight such risks and propose changes to support...